Degrees:
Ph.D., Univ. of California, Irvine
B.S., Tufts Univ.
Dr. Masino is the Vernon D. Roosa Professor of Applied Science at Trinity College and a joint appointment in Neuroscience and Psychology. Her research focuses on promoting and restoring brain health, with a particular interest in adenosine, and on the relationship among metabolism, brain activity and behavior. For nearly 100 years a metabolic therapy called a “ketogenic diet” has been used to treat seizures, and recent mechanistic insights - including the role of adenosine – hold translational implications for brain health and diverse disorders.
In addition to her laboratory research Dr. Masino is interested in how public policies can improve brain health. During 2018-2019 she was a Charles Bullard Fellow in Forest Research at Harvard and published the seminal paper on the benefits of proforestation (linked below) for climate change mitigation, biodiversity, and public health. She has also published papers and policies on natural stewardship of forest ecosystems.
"At its best, a liberal arts environment is where students and faculty alike achieve their full potential. Trinity understands that students learn more and retain more when they interact with scholars and teachers who are passionate about what they do and can help students find their own passion.
At Trinity I have opportunities to collaborate with students and share ideas, share my enthusiasm for research, and facilitate students moving on from Trinity feeling self-empowered to have a positive impact on their health and on local and global issues facing us today."
Check out her edited book, updated to the second edition in honor of the 100th Anniversary of the Ketogenic Diet, and her Inaugural Lecture as the Vernon D. Roosa Professor of Applied Science.
Here is a link to a summary of Professor Masino's research.
Here is a link to the seminal paper on proforestation and a ~3 min audio interview on NEPR.
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Drugs and behavior
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The neurobiology of learning and memory
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Behavioral neuroscience
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Neurophysiology
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Neuroscience methods
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Brain and behavior
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Current issues in neuroscience
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Role and regulation of adenosine in the nervous system
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Ketogenic diet
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Clinical conditions such as epilepsy, pain and autism
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Brain health
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Recent and selected publications (*Trinity undergraduate):
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Complete list of publications
- Research overview in Scientia with nice images and recent publications.
- Masino, S.A., Li, T., Theofilas, P., Sandau, U.S., Ruskin D.N., Fredholm, B.B., Geiger, J.D., Aronica, E., & Boison D. (2011) A ketogenic diet suppresses seizures in mice through adenosine A1 receptors. Journal of Clinical Investigation, 121(7): 2679-2683.
- Boison, D., Masino S.A. & Geiger J.D. (2011) Homeostatic bioenergetic network regulation – a novel concept to avoid pharmacoresistance in epilepsy. Expert Opinion in Drug Development, 6(7): 713-724.
- Ruskin, D.N., Ross. J.*, Kawamura, M. Jr., Ruiz, T.*, Geiger, J.D. & Masino, S.A. (2011) A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington’s Disease. Physiology and Behavior, 103(5): 501-507.
- Kawamura M., Ruskin D.N., Masino S.A. (2010) Metabolic autocrine regulation of neurons involves cooperation among pannexin hemichannels, adenosine receptors and KATP channels. Journal of Neuroscience, 30(11): 3886-3895.
- Masino, S.A., Kawamura, M., Wasser, C.D.*, Pomeroy, L.T.*, Ruskin, D.N. (2009) Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity. Current Neuropharmacology, 7(3), 257-268.
- Ruskin, D.N., Kawamura M., Masino S.A. (2009) Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet. PLoS ONE, 4(12):e8349.
- Masino, S.A. and Geiger, J.D. (2008) Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets? Trends in Neurosciences, 6: 273-278.
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- Charles Bullard Fellow, Harvard Forest, 2018-2019
- Trustee Award for Faculty Excellence, 2012
- NIH R15 NS066392 "Effects of a Ketogenic Diet on Regional Brain Energy and Plasticity," 09/10-8/12
- NSF IOS-0848535 "RUI: Physiological regulation of ATP and adenosine: linking metabolism to neuronal excitability," 06/09-05/12
- Charles A. Dana Research Associate Professor, Trinity College, 2009-2011
- NIH R15 NS061290 "The Modulation of Adenosine by Temperature, Oxygen and Glucose," 12/07-8/10
- Mary Simone Erskine Award for Excellence in Mentoring, Research Training and Scholarship, 2009
- Finalist: Connecticut Women of Innovation, Connecticut Technology Council - Research Innovation, 2007; Academic Innovation, 2008; Community Innovation, 2009
- CHDI Foundation Discovery Award, 11/08-10/09
- Annette and Kingsbury Browne Conservation Volunteer of the Year Award, 2008
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