Professor Prigodich received a B.A. in Chemistry from Lake Forest College in 1974. For several years he worked with deaf-blind children and students with learning disabilities before returning to chemistry. He received his Ph.D. in Physical Organic Chemistry from Wesleyan University in 1982 for his research on reactive organophosphorus compounds. From 1982-85 he was a NIH Post-Doctoral Fellow in the Molecular Biophysics and Biochemistry Department at Yale University using nuclear magnetic resonance to investigate protein-ligand interactions. He joined the Trinity College faculty in 1985.

The attraction of Trinity for Professor Prigodich was the teacher/scholar paradigm adopted by the Trinity College faculty. This provides the opportunity to reinforce the lessons taught in the classroom with experience in the research laboratory. Professor Prigodich’s research interests still center on the interactions between proteins and the other biomolecules that they bind by using a variety of physical chemical techniques. Approximately 30 of the many students who have collaborated in Professor Prigodich’s research program have gone on to receive M.D.’s and Ph.D.’s.

• M. Buckley, A. Walker, S. Y. W. Ho, Y. Yang, C. Smith, P. Ashton, J. T. Oates, E. Cappellini, H. Koon, K. Penkman, B. Elsworth, D. Ashford, C. Solazzo, P. Andrews, J. Strahler, B. Shapiro, P. Ostrom, H. Gandhi, W. Miller, B. Raney, M. I. Zylber, M. T. P. Gilbert, R. V. Prigodich, M. Ryan, K. F. Rijsdijk, A. Janoo, and M. J. Collins, “Comment on ‘Protein Sequences from Mastodon and Tyrannosaurus rex Revealed by Mass Spectrometry’ " Science (2008) 319, 33c.
• C. I. Smith, O. E. Craig, R. V. Prigodich, C. M. Nielsen-Marsh, M. M. E. Jans, C. Vermeer, M. J. Collins, "Diagenesis and survival of osteocalcin in archaeological bone," Journal of Archaeological Science 32, 1 (2005):105-113.
• M. J. Collins, C. Nielsen-Marsh, J. Hiller, C. I. Smith, J. P. Roberts, R. V. Prigodich, T. J. Wess, J. Csapo, A. R. Millard, G. Turner-Walker, "Bone Diagenesis; implications for heritage management," in The Future from the Past: Archaeolozoology in Wildlife Conservation and Heritage Management (R. C. G. M. Lauwerier and I. Plug, Eds.), Chapter 12, (2004):124-132.
• M. J. Collins, C. Nielsen-Marsh, J. Hiller, C. Smith, J. Roberts, R. Prigodich, T. Wess, J. Csapo, A. Millard, G. Turner-Walker, “The Survival of Organic Matter in Bone: A Review,” Archaeometry 44, 3(2002):383-394.
• R. V. Prigodich and M. Vesely*, "Characterization of the Complex between Bovine Osteocalcin and Type I Collagen," Archives of Biochemistry and Biophysics, 345 (1997):339-341.
• R.V. Prigodich and M. Zager*, "Indexing Crystal Faces", Powder Diffraction, 10, 2 (1995):127-128.
• R.V. Prigodich and A. Sanaulla*, "Measurement of the Fluorescence Quenching Constants of 3-Nitrotyrosine with N-Acetyltryptophanamide," Journal of Chemical Research, 3 (1991):66-67.
• R.V. Prigodich and C.T. Martin, "Reaction of Single-Stranded DNA with Hydroxyl Radical Generated by Iron(II)-Ethylenediaminetetraacetic Acid," Biochemistry 29 (1990):8017-8019.
• J.E. Coleman, K.R. Williams, G.C. King, R.V. Prigodich, Y. Shamoo and W.H. Konigsberg, "Mapping the Functional Domains in the ssDNA Binding Proteins Gene 5 and Gene 32", in Protein Engineering (D.L. Oxender and C.F. Fox, Eds.), chapter 30, (1987):323-336.
• R.V. Prigodich, Y. Shamoo, K.R. Williams, J.W. Chase, W.H. Konigsberg and J.E. Coleman,"1H NMR (500 MHz) Identification of Aromatic Residues of Gene 32 Protein Involved in DNA Binding by the Use of Protein Containing Perdeuterated Aromatic Residues and by Site-Directed Mutagenesis", Biochemistry, 25 (1986):3666-3672.
• J.E. Coleman, K.R. Williams, G.C. King, R.V. Prigodich, Y. Shamoo and W.H. Konigsberg, "Protein Chemistry-Nuclear Magnetic Resonance Approach to Mapping Functional Domains in Single-Stranded DNA Binding Proteins," Journal of Cellular Biochemistry, 32 (1986):305-326.

* Trinity Student Author

Honors/Awards

• NIH Senior International Fellow, Oxford University, 1990.
• NIH Post-Doctoral Fellowship, Yale University, 1982-85.
• Petersson Fellowship, Wesleyan University, 1981.
• Phi Beta Kappa, Lake Forest College, 1974. 

Grants

• NSF Shared Instrumentation Grant. “Acquisition of a 400 MHz NMR Spectrometer”
  Grant Active 1/07 – $308,000. Co-PI’s: Timothy Curran and Richard Prigodich
• National Institutes of Health-Academic Research Enhancement Award (AREA). "Footprinting Protein Complexes with Single-Stranded DNA".
  Grant Active 7/95 to 6/99 - $108,300. Richard Prigodich
• National Science Foundation Shared Instrumentation Program. "High Resolution 500 MHz Biological NMR Facility"
  Co-PI’s: Dr. Irina Russu - Wesleyan University, Dr. Philip Bolton - Wesleyan University
  Grant Active: 9/95 - $300,000
• Arthritis Foundation. "Structure of Hydroxyapatite and Osteocalcin
  Grant Active 6/92 - 5/95 - $75,000
• National Science Foundation Shared Instrumentation Program. "Solid State NMR Facility"
  P.I.: Dr. Lynmarie Thompson - University of Massachusetts. Grant Active 10/92 - $250,000
• National Institutes of Health-Academic Research Enhancement Award (AREA). "Solution and Solid State Structure and Function of Osteocalcin".
  Grant Active 9/86 to 9/88 - $63,176.00. PI: Richard Prigodich