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Degrees:
Ph.D., Univ. of California, Irvine
B.S., Tufts Univ.
Dr. Masino is the Paul E. Raether Distinguished Professor of Applied Science at Trinity College and a joint appointment in Neuroscience and Psychology. Her research focuses on promoting and restoring brain health, with a particular interest in adenosine, and on the relationship among metabolism, brain activity and behavior. For nearly 100 years a metabolic therapy called a “ketogenic diet” has been used to treat seizures, and recent mechanistic insights - including the role of adenosine – hold translational implications for brain health and diverse disorders. She is a founding member of the International Neurological Ketogenic Society
In addition to her laboratory research Dr. Masino is interested in how public policies can improve brain health. During 2018-2019 she was a Charles Bullard Fellow in Forest Research at Harvard and published the seminal paper on the benefits of proforestation (linked below) for climate stabilization, biodiversity, and public health.
"At its best, a liberal arts environment is where students and faculty alike achieve their full potential. Trinity understands that students learn more and retain more when they interact with scholars and teachers who are passionate about what they do and can help students find their own passion.
At Trinity I have opportunities to collaborate with students and share ideas, share my enthusiasm for research, and facilitate students moving on from Trinity feeling self-empowered to have a positive impact on their health and on local and global issues facing us today."
Here is her biomedical work on PubMed and cross-disciplinary publications on Google Scholar since 2019. She has also published policies and reports on natural stewardship of forest ecosystems and is a coauthor of the major regional report titled " Wildlands in New England: Past, Present, and Future."
Check out her edited book, updated to the second edition in honor of the 100th Anniversary of the Ketogenic Diet, her Inaugural Lecture as the Vernon D. Roosa Professor of Applied Science, and a recent piece in the Transmitter based on a special recognition award from the Society for Neuroscience
Locally, has been advocating for the old forests in Hartford and beyond, and the legacy of Frederick Law Olmsted, who is born and buried in Hartford. Here is a curated series of experts on Olmsted, Nature, Science and Health, and she is working with her students a new project about Olmsted in Hartford, featuring Keney Park and the Ten Mile Woods. She also working nationally with www.RESTORE.org on plans for new National Parks, especially in areas that lack National Parks.
Here is a link to the seminal paper on proforestation (2019) and a ~3 min audio interview on NEPR.
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Drugs and behavior
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The neurobiology of learning and memory
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Behavioral neuroscience
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Neurophysiology
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Neuroscience methods
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Brain and behavior
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Current issues in neuroscience
FYSM-158
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The Green Mind
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NESC-109
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Your Brain on Nature: The Benefits of Places Great and Small
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PSYC-261
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Brain and Behavior
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PSYC-261
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Brain and Behavior Laboratory
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PSYC-402
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Senior Seminar: Embracing Nature's Complexity, Inside and Out
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Role and regulation of adenosine in the nervous system
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Ketogenic diet
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Clinical conditions such as epilepsy, pain and autism
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Brain health
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Recent and selected publications (*Trinity undergraduate):
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Complete list of publications
- Research overview in Scientia with nice images and recent publications.
- Masino, S.A., Li, T., Theofilas, P., Sandau, U.S., Ruskin D.N., Fredholm, B.B., Geiger, J.D., Aronica, E., & Boison D. (2011) A ketogenic diet suppresses seizures in mice through adenosine A1 receptors. Journal of Clinical Investigation, 121(7): 2679-2683.
- Boison, D., Masino S.A. & Geiger J.D. (2011) Homeostatic bioenergetic network regulation – a novel concept to avoid pharmacoresistance in epilepsy. Expert Opinion in Drug Development, 6(7): 713-724.
- Ruskin, D.N., Ross. J.*, Kawamura, M. Jr., Ruiz, T.*, Geiger, J.D. & Masino, S.A. (2011) A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington’s Disease. Physiology and Behavior, 103(5): 501-507.
- Kawamura M., Ruskin D.N., Masino S.A. (2010) Metabolic autocrine regulation of neurons involves cooperation among pannexin hemichannels, adenosine receptors and KATP channels. Journal of Neuroscience, 30(11): 3886-3895.
- Masino, S.A., Kawamura, M., Wasser, C.D.*, Pomeroy, L.T.*, Ruskin, D.N. (2009) Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity. Current Neuropharmacology, 7(3), 257-268.
- Ruskin, D.N., Kawamura M., Masino S.A. (2009) Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet. PLoS ONE, 4(12):e8349.
- Masino, S.A. and Geiger, J.D. (2008) Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets? Trends in Neurosciences, 6: 273-278.
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- Charles Bullard Fellow, Harvard Forest, 2018-2019
- Trustee Award for Faculty Excellence, 2012
- NIH R15 NS066392 "Effects of a Ketogenic Diet on Regional Brain Energy and Plasticity," 09/10-8/12
- NSF IOS-0848535 "RUI: Physiological regulation of ATP and adenosine: linking metabolism to neuronal excitability," 06/09-05/12
- Charles A. Dana Research Associate Professor, Trinity College, 2009-2011
- NIH R15 NS061290 "The Modulation of Adenosine by Temperature, Oxygen and Glucose," 12/07-8/10
- Mary Simone Erskine Award for Excellence in Mentoring, Research Training and Scholarship, 2009
- Finalist: Connecticut Women of Innovation, Connecticut Technology Council - Research Innovation, 2007; Academic Innovation, 2008; Community Innovation, 2009
- CHDI Foundation Discovery Award, 11/08-10/09
- Annette and Kingsbury Browne Conservation Volunteer of the Year Award, 2008
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