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Degrees:
Ph.D., Harvard Univ.
M.A., Harvard Univ.
B.S., Univ. of Chicago
Donald J. Wolanin, Ph.D., is an accomplished educator and research professional, blending a distinguished academic journey with a substantial background in pharmaceutical research. A Harvard University graduate with a Ph.D. in Chemistry, he also holds a B.S. in Chemistry from the University of Chicago. Dr. Wolanin's early career featured roles as Head Teaching Fellow at Harvard and positions at ICI Pharmaceuticals Group (now Astra-Zeneca). At Bayer Corporation, he progressed from Senior Staff Scientist to Director of Research, showcasing expertise in research management and strategic program support. He contributed to the successful identification of preclinical development candidates in several therapeutic areas, including cancer, arthritis and diabetes.
Transitioning to academia, he became an Adjunct Faculty Member at institutions such as Yale University and Fairfield University, teaching Organic Chemistry, General Chemistry, and Chemistry for Health Sciences. Dr. Wolanin's teaching philosophy emphasizes integrating theoretical knowledge with practical applications.
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CHEM-212
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Elementary Organic Chemistry II
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Developing structure-activity relationships of medicinal agents
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Total synthesis of natural products
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Synthetic methodology
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- C. A. Veale, P. R. Bernstein, C. M. Bohnert, F. J. Brown, C. Bryant, J. R. Damewood, Jr., R. Earley, S. W. Feeney, P. D. Edwards, B. Gomes, J. M. Hulsizer, B. J. Kosmider, R. D. Krell, G. Moore, T. W. Salcedo, A. Shaw, D. S. Silberstein, G. B. Steelman, M. Stein, A. Strimpler, R. M. Thomas, E. P. Vacek, J. C. Williams, D. J. Wolanin, S. Woolson, "Orally Active Trifluoromethyl Ketone Inhibitors of Human Leukocyte Elastase", J. Med. Chem. 40, 3173 (1997).
- P. D. Edwards, D. W. Andisik, C. A. Bryant, B. Ewing, B. Gomes, J. L. Lewis, D. Rakiewicz,G. Steelman, A. Strimpler, D. A. Trainor, P. A. Tuthill, R. C. Mauger, C. A. Veale, R. A. Wildonger, J. C. Williams, D. J. Wolanin and M. Zottola, "Discovery and Biological Activity of Orally Active Peptidyl Trifluoromethyl Ketone Inhibitors of Human Neutrophil Elastase", J. Med. Chem. 40, 1876 (1997).
- P. R. Bernstein, C. Bryant, C. Ceccarelli, J. R. Damewood, Jr., R. Earley, S. W. Feeney, B. C. Gomes, B. J. Kosmider, G. B. Steelman, R. M. Thomas, E. P. Vacek, J. C. Williams, D. J. Wolanin, S. A. Woolson and C. A. Veale, "Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis and X-Ray Crystallography of a Series of Orally Active 5-Amino Pyrimidin-6-ones", J. Med. Chem. 38, 98 (1995).
- P. R. Bernstein, D. W. Andisik, P. K. Bradley, C. B. Bryant, C. Ceccarelli, J. R. Damewood, Jr., R. Earley, P. D. Edwards, S. Feeney, B. C. Gomes, B. J. Kosmider, G. B. Steelman, R. M. Thomas, E. P. Vacek, C. A. Veale, J. C. Williams, D. J. Wolanin and S. A. Woolson, "Nonpeptidic Inhibitors of Human Leukocyte Elastase. 3.Design, Synthesis, X-Ray Crystallographic Analysis and Structure-Activity Relationships for a Series of Orally Active 3-Amino-6-Phenylpyridin-2-ones", J. Med.Chem. 37, 3313 (1994).
- J. R. Damewood, Jr., P. D. Edwards, S. Feeney, B. Gomes, G. B. Steelman, P. A. Tuthil J. C. Williams, P. Warner, S. A. Woolson, D. J. Wolanin and C. A. Veale, "Nonpeptidic Inhibitors of Human Leukocyte Elastase. 2. Design, Synthesis and in Vitro Activity of a Series of 3-Amino-6-arylopyridin-2-one Trifluoromethylketones", J. Med. Chem. 37, 3303 (1994).
- F. J. Brown, D. W. Andisik, P. R. Bernstein, C. B. Bryant, C. Ceccarelli, J. R. Damewood, Jr., P. D. Edwards, R. A. Earley, S. W. Feeney, R. C. Green, B. Gomes, B. J. Kosmider, R. D. Krell, A. Shaw, G. B. Steelman, R. M. Thomas, E. P. Vacek, C. A. Veale, P. A. Tuthill, P. Warner, J. C. Williams, D. J. Wolanin and S. A. Woolson, "The Design of Orally Active, Non-Peptidic Inhibitors of Human Leukocyte Elastase", J. Med. Chem. 37, 1261 (1994).
- D. J. Wolanin and J. B. Campbell, "Pulmonary and Antiallergy Agents" in Annual Reports in Medicinal Chemistry, Vol. 26, J. Bristol ed., Academic Press (1991), pp. 113-122.
- A. Shaw, R. A. Roberts and D. J. Wolanin, "Small Substrates and Inhibitors of the Metalloprotease of Rabbit Articular Chondrocytes" in New Perspectives in Anti-Inflammatory Therapies, Advances in Inflammation Research, Vol. 12, A. Lewis, N. Ackerman and I. Otterness eds., Raven Press (1988), pp. 67-79.
- C. B. Caputo, L. A. Sygowski, S. P. Patton, D. J. Wolanin, A. Shaw, R. A. Roberts and G. DiPasquale, "Protease Inhibitors Decrease Rabbit Cartilage Degradation After Meniscectomy", J. Orthop. Res. 6, 103 (1988).
- P. A. Wender and D. J. Wolanin, "Total Synthesis of Quadrone and Terrecyclic Acid A", J. Org. Chem. 50, 4418 (1985).
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- Bayer President’s Achievement Award Finalist, Accelerated Drug Development Team, 1998
- Bayer Special Recognition Award (Chemistry Building Design and Approval), 1997
- Bayer Quality Excellence Award (Osteoarthritis Cross-functional Team), 1996
- Miles Inc. Special Recognition Award (Safety Program Management), 1993
- ICI Chemistry Award Committee Chair, 1988
- Phi Beta Kappa, University of Chicago Chapter, 1977
- National Science Foundation Summer Fellowship, 1976
- Author or co-author on 25 granted patents, 16 publications
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