Degrees:
Ph.D., Univ. of Michigan
B.S., Univ. of Puerto Rico
Prof. Guardiola-Diaz is a biochemist interested in signaling mechanisms that modulate cellular function in the nervous system. She joined the Trinity faculty in 1998. |
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Biochemistry
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Molecular Neurobiology
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Oligodendrocyte Biology
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Growth Factor Signaling
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Biochemistry and molecular biology of nuclear receptors
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Molecular neurobiology
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Publications:
- Diverse responses of oligodendrocytes to different FGF-family members:
Uncoupling structure-function relationship within FGF subfamilies.
Manuscript in preparation. Guardiola-Diaz H, DiBenedictis BT, Ahamed S, Wark GM, Prendaj E, & Bansal R. (2023)
- Guardiola-Diaz, H. M. Ishii, A. & Bansal, R. (2011) Erk1/2 MAPK
and mTOR signaling sequentially regulates progression through distinct
stages of oligodendrocyte differentiation. Glia, 60(3):476-86.
- Zanno, A., Kwiatkowski, N., Vaz, A.D. & Guardiola-Diaz, H. M. (2005) MT FdxR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51. Biochimica et Biophysica Acta, 1707 (2-3):157-69.
- Magge, S. S. & Guardiola-Diaz, H. M. (2002) Characterization of
the mouse peroxisome proliferator-activated receptor delta gene.
Biochemical and Biophysical Research Communications, 290, 230-235.
- Guardiola-Diaz, H. M., Foster, L.-A., Mushrush, D.
& Vaz, A. (2001) Azole-antifungal binding to a novel
cytochrome P450 from Mycobacterium tuberculosis: implications
for treatment of tuberculosis. Biochemical Pharmacology,
61, 1463-1470.
- Guardiola-Diaz, H. M., Rehnmark, S., Usuda, N., Albrektsen, T.,
Feltkamp, D., Gustafsson, J.-A. & Alexson, S. E. (1999) Rat
peroxisome proliferator-activated receptors and brown adipose tissue function during cold acclimatization. Journal of
Biological Chemistry, 274(33), 23368-23377.
Presentations:
- Guardiola-Diaz, H. M. "Estrategias nuevas para combatir M. tuberculosis." Lecture presented at Congreso Latinoamericano de Estudiantes de Microbiologia y Parasitologia (Latinamerican Congress for Microbiology and Parasitology Students) in Lima, Peru, 2005.
- Guardiola-Diaz, H. M. "PPARd Enhances Expression of Myelin Proteins in Oligodendrocytes and C6 Cells." Society for Neuroscience Abstracts, 2004, p.69.
- Guardiola-Diaz, H., Zanno, A., Kwiatkowski, N., and Vaz, A. "Identification and characterization of the reductase component of the M. tuberculosis CYP51 system." 21st Annual New England Membrane Enzyme Group Meeting, 2004.
- Guardiola-Diaz, H. "Tuberculosis: Could Mycobacterial Cytochrome P450s Become Novel Therapeutic Targets?" Invited lecture at the 21st Annual New England Membrane Enzyme Group Meeting in Newport, RI, 2004.
- Guardiola-Diaz, H. M., and Magge, S. "PPARd -regulated genes in oligodendrocytes." Society for Neuroscience Abstracts, 27 (2001): 462.
- Guardiola-Diaz, H. M., Foster, L.-A., and Vaz, A. "Anti-mycobacterial activity of azole-antifungals: Implications for potential new therapeutic targets in M. tuberculosis." 11th International Conference on Cytochrome P450. Sendai Japan, 1999, 170.
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- Visiting Professor of Medical Biochemistry Moi Univ. School of Medicine; Eldoret, Kenya, 2005
- American Society for Biochem. and Molecular Biology Travel Award, 2002
- Green Circle Award, State of Connecticut Department of Environmental Protection, 2000
- Pfizer Grant ($10,000), 1999
- Wenner Gren Foundation Post-Doctoral Fellowship, 1996
- Swedish Medical Research Council Fellowship, 1994
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